The Modeling Network for Serious Infectious Diseases (MONID) has released a second statement after its first one in September on the further course of the SARS-CoV-2 pandemic in autumn and winter of 2022/2023. In connection with the current debate, the second statement contains new modelling results on the possible effects of a repeal of the obligatory isolation and a withdrawal of the mandatory use of masks in public transport. In the second statement, in addition to COVID-19, other severe respiratory infections are also taken into account, which currently cause a strongly increased incidence of hospital admissions in Germany.