{"id":2203,"date":"2018-08-10T09:41:12","date_gmt":"2018-08-10T07:41:12","guid":{"rendered":"https:\/\/webszh.uk-halle.de\/loewenkids\/?page_id=2203"},"modified":"2023-05-23T15:32:11","modified_gmt":"2023-05-23T13:32:11","slug":"pre-study-for-feasability","status":"publish","type":"page","link":"https:\/\/webszh.uk-halle.de\/loewenkids\/en\/pre-study-for-feasability\/","title":{"rendered":"Pre-study for feasability"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2203\" class=\"elementor elementor-2203\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7c54771 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7c54771\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3d3f37a\" data-id=\"3d3f37a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-32c6fa6 elementor-widget elementor-widget-spacer\" data-id=\"32c6fa6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3a4800f elementor-widget elementor-widget-heading\" data-id=\"3a4800f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-large\">PRELIMINARY STUDY ON FEASIBILITY<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e8d40d0 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"e8d40d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-491663f elementor-widget elementor-widget-spacer\" data-id=\"491663f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2f97572 elementor-widget elementor-widget-text-editor\" data-id=\"2f97572\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>As part of the preliminary study, we wanted to test the materials we had developed for recording colds and gastrointestinal diseases in small children. We also collected initial data regarding the frequency of infections in small children in day-care centers. The preliminary study was conducted from November 2013 to June 2014.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ab3d701 elementor-widget elementor-widget-spacer\" data-id=\"ab3d701\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e1a3fdb elementor-hidden-mobile elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"e1a3fdb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-child\" viewBox=\"0 0 384 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M120 72c0-39.765 32.235-72 72-72s72 32.235 72 72c0 39.764-32.235 72-72 72s-72-32.236-72-72zm254.627 1.373c-12.496-12.497-32.758-12.497-45.254 0L242.745 160H141.254L54.627 73.373c-12.496-12.497-32.758-12.497-45.254 0-12.497 12.497-12.497 32.758 0 45.255L104 213.254V480c0 17.673 14.327 32 32 32h16c17.673 0 32-14.327 32-32V368h16v112c0 17.673 14.327 32 32 32h16c17.673 0 32-14.327 32-32V213.254l94.627-94.627c12.497-12.497 12.497-32.757 0-45.254z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\"><b>Who took part in the study?<\/b> A total of 75 parents took part with their children. The children came from 24 different day-care centers. Per day-care center, 1 to 9 parents agreed to take part in the preliminary-study. The children (34 boys, 41 girls) were on average 24 months old at the start of the study.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-book-open\" viewBox=\"0 0 576 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M542.22 32.05c-54.8 3.11-163.72 14.43-230.96 55.59-4.64 2.84-7.27 7.89-7.27 13.17v363.87c0 11.55 12.63 18.85 23.28 13.49 69.18-34.82 169.23-44.32 218.7-46.92 16.89-.89 30.02-14.43 30.02-30.66V62.75c.01-17.71-15.35-31.74-33.77-30.7zM264.73 87.64C197.5 46.48 88.58 35.17 33.78 32.05 15.36 31.01 0 45.04 0 62.75V400.6c0 16.24 13.13 29.78 30.02 30.66 49.49 2.6 149.59 12.11 218.77 46.95 10.62 5.35 23.21-1.94 23.21-13.46V100.63c0-5.29-2.62-10.14-7.27-12.99z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\"><b>Keeping a symptom diary:<\/b> We asked parents to keep a diary of their child's symptoms for three months. We received a fully completed symptom diary (90 days) from 41 parents (54.7%), another 17 parents (22.7%) filled in more than 74 days. Thanks to the information in the feasibility questionnaire and in interviews conducted with the parents, we were able to optimize the symptom diary for use in the long-term study.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-thermometer\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M476.8 20.4c-37.5-30.7-95.5-26.3-131.9 10.2l-45.7 46 50.5 50.5c3.1 3.1 3.1 8.2 0 11.3l-11.3 11.3c-3.1 3.1-8.2 3.1-11.3 0l-50.4-50.5-45.1 45.4 50.3 50.4c3.1 3.1 3.1 8.2 0 11.3l-11.3 11.3c-3.1 3.1-8.2 3.1-11.3 0L209 167.4l-45.1 45.4L214 263c3.1 3.1 3.1 8.2 0 11.3l-11.3 11.3c-3.1 3.1-8.2 3.1-11.3 0l-50.1-50.2L96 281.1V382L7 471c-9.4 9.4-9.4 24.6 0 33.9 9.4 9.4 24.6 9.4 33.9 0l89-89h99.9L484 162.6c34.9-34.9 42.2-101.5-7.2-142.2z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\"><b>What symptoms did you experience?<\/b> We have information on the occurrence of symptoms of a cold or gastrointestinal disease in the participating children for a total of 5584 days. The children had rhinitis, noted by a stuffy or runny nose, on just over a third of the days. The second most common symptom was coughing.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-vials\" viewBox=\"0 0 640 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M72 64h24v240c0 44.1 35.9 80 80 80s80-35.9 80-80V64h24c4.4 0 8-3.6 8-8V8c0-4.4-3.6-8-8-8H72c-4.4 0-8 3.6-8 8v48c0 4.4 3.6 8 8 8zm72 0h64v96h-64V64zm480 384H16c-8.8 0-16 7.2-16 16v32c0 8.8 7.2 16 16 16h608c8.8 0 16-7.2 16-16v-32c0-8.8-7.2-16-16-16zM360 64h24v240c0 44.1 35.9 80 80 80s80-35.9 80-80V64h24c4.4 0 8-3.6 8-8V8c0-4.4-3.6-8-8-8H360c-4.4 0-8 3.6-8 8v48c0 4.4 3.6 8 8 8zm72 0h64v96h-64V64z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\"><b>Taking nasal swab and stool samples:<\/b> We also asked the parents to take nasal swab and stool samples from their child monthly to fixed times (three times in total) and once when symptoms of disease arose. We received three or more stool samples from 58 families (77.3%) and three or more nasal swab samples from 49 families (65.3%). We examined the nasal swabs of when cold symptoms appeared for the presence of cold viruses. Figure 1 shows which viruses we were able to detect in the nasal swab samples.<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f701f51 elementor-hidden-desktop elementor-hidden-tablet elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"f701f51\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-child\" viewBox=\"0 0 384 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M120 72c0-39.765 32.235-72 72-72s72 32.235 72 72c0 39.764-32.235 72-72 72s-72-32.236-72-72zm254.627 1.373c-12.496-12.497-32.758-12.497-45.254 0L242.745 160H141.254L54.627 73.373c-12.496-12.497-32.758-12.497-45.254 0-12.497 12.497-12.497 32.758 0 45.255L104 213.254V480c0 17.673 14.327 32 32 32h16c17.673 0 32-14.327 32-32V368h16v112c0 17.673 14.327 32 32 32h16c17.673 0 32-14.327 32-32V213.254l94.627-94.627c12.497-12.497 12.497-32.757 0-45.254z\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\t<b>Who took part in the study?<\/b><br> A total of 75 parents took part with their children. The children came from 24 different day-care centers. Per day-care center, 1 to 9 parents agreed to take part in the preliminary-study. The children (34 boys, 41 girls) were on average 24 months old at the start of the study.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-21b2b04 elementor-hidden-desktop elementor-hidden-tablet elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"21b2b04\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-book-open\" viewBox=\"0 0 576 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M542.22 32.05c-54.8 3.11-163.72 14.43-230.96 55.59-4.64 2.84-7.27 7.89-7.27 13.17v363.87c0 11.55 12.63 18.85 23.28 13.49 69.18-34.82 169.23-44.32 218.7-46.92 16.89-.89 30.02-14.43 30.02-30.66V62.75c.01-17.71-15.35-31.74-33.77-30.7zM264.73 87.64C197.5 46.48 88.58 35.17 33.78 32.05 15.36 31.01 0 45.04 0 62.75V400.6c0 16.24 13.13 29.78 30.02 30.66 49.49 2.6 149.59 12.11 218.77 46.95 10.62 5.35 23.21-1.94 23.21-13.46V100.63c0-5.29-2.62-10.14-7.27-12.99z\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\t<b>Keeping a symptom diary:<\/b><br>We asked parents to keep a diary of their child's symptoms for three months. We received a fully completed symptom diary (90 days) from 41 parents (54.7%), another 17 parents (22.7%) filled in more than 74 days. Thanks to the information in the feasibility questionnaire and in interviews conducted with the parents, we were able to optimize the symptom diary for use in the long-term study.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5abe426 elementor-hidden-desktop elementor-hidden-tablet elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"5abe426\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-thermometer\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M476.8 20.4c-37.5-30.7-95.5-26.3-131.9 10.2l-45.7 46 50.5 50.5c3.1 3.1 3.1 8.2 0 11.3l-11.3 11.3c-3.1 3.1-8.2 3.1-11.3 0l-50.4-50.5-45.1 45.4 50.3 50.4c3.1 3.1 3.1 8.2 0 11.3l-11.3 11.3c-3.1 3.1-8.2 3.1-11.3 0L209 167.4l-45.1 45.4L214 263c3.1 3.1 3.1 8.2 0 11.3l-11.3 11.3c-3.1 3.1-8.2 3.1-11.3 0l-50.1-50.2L96 281.1V382L7 471c-9.4 9.4-9.4 24.6 0 33.9 9.4 9.4 24.6 9.4 33.9 0l89-89h99.9L484 162.6c34.9-34.9 42.2-101.5-7.2-142.2z\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\t<b>What symptoms did you experience?<\/b><br>We have information on the occurrence of symptoms of a cold or gastrointestinal disease in the participating children for a total of 5584 days. The children had rhinitis, noted by a stuffy or runny nose, on just over a third of the days. The second most common symptom was coughing.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e6b9665 elementor-hidden-desktop elementor-hidden-tablet elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"e6b9665\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-vials\" viewBox=\"0 0 640 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M72 64h24v240c0 44.1 35.9 80 80 80s80-35.9 80-80V64h24c4.4 0 8-3.6 8-8V8c0-4.4-3.6-8-8-8H72c-4.4 0-8 3.6-8 8v48c0 4.4 3.6 8 8 8zm72 0h64v96h-64V64zm480 384H16c-8.8 0-16 7.2-16 16v32c0 8.8 7.2 16 16 16h608c8.8 0 16-7.2 16-16v-32c0-8.8-7.2-16-16-16zM360 64h24v240c0 44.1 35.9 80 80 80s80-35.9 80-80V64h24c4.4 0 8-3.6 8-8V8c0-4.4-3.6-8-8-8H360c-4.4 0-8 3.6-8 8v48c0 4.4 3.6 8 8 8zm72 0h64v96h-64V64z\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\t<b>Taking nasal swab and stool samples:<\/b><br>We also asked the parents to take nasal swab and stool samples from their child monthly to fixed times (three times in total) and once when symptoms of disease arose. We received three or more stool samples from 58 families (77.3%) and three or more nasal swab samples from 49 families (65.3%). We examined the nasal swabs of when cold symptoms appeared for the presence of cold viruses. Figure 1 shows which viruses we were able to detect in the nasal swab samples.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-756a364 elementor-widget elementor-widget-spacer\" data-id=\"756a364\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-315bc7c elementor-widget elementor-widget-image\" data-id=\"315bc7c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"600\" height=\"441\" src=\"https:\/\/webszh.uk-halle.de\/loewenkids\/wp-content\/uploads\/2018\/08\/csm_Legende_Viren_a8ec1149a9.png\" class=\"attachment-medium_large size-medium_large wp-image-220\" alt=\"\" srcset=\"https:\/\/webszh.uk-halle.de\/loewenkids\/wp-content\/uploads\/2018\/08\/csm_Legende_Viren_a8ec1149a9.png 600w, https:\/\/webszh.uk-halle.de\/loewenkids\/wp-content\/uploads\/2018\/08\/csm_Legende_Viren_a8ec1149a9-300x221.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Abbildung 1: Virusfunde in den 42 Nasenabstrichen bei Symptomen (in %)<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a69db58 elementor-widget elementor-widget-spacer\" data-id=\"a69db58\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d0965c6 elementor-hidden-desktop elementor-hidden-tablet elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"d0965c6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-check-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M504 256c0 136.967-111.033 248-248 248S8 392.967 8 256 119.033 8 256 8s248 111.033 248 248zM227.314 387.314l184-184c6.248-6.248 6.248-16.379 0-22.627l-22.627-22.627c-6.248-6.249-16.379-6.249-22.628 0L216 308.118l-70.059-70.059c-6.248-6.248-16.379-6.248-22.628 0l-22.627 22.627c-6.248 6.248-6.248 16.379 0 22.627l104 104c6.249 6.249 16.379 6.249 22.628.001z\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\t<b>How did the parents rate each element of the study?<\/b><br>For 92.3% of the parents, completing the symptom diary did not take too long or all that long. 67.2% felt that carrying out the nasal swabs was either of little difficulty or not difficult at all. The most common problem reported with nasal swabs was that children were crying or struggling. 86% rated taking the stool sample to be only somewhat unpleasant or not unpleasant at all. The written instructions for the extraction were found to be understandable by everyone (agree\/strongly agree).\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1264f8a elementor-hidden-mobile elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"1264f8a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-check-circle\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M504 256c0 136.967-111.033 248-248 248S8 392.967 8 256 119.033 8 256 8s248 111.033 248 248zM227.314 387.314l184-184c6.248-6.248 6.248-16.379 0-22.627l-22.627-22.627c-6.248-6.249-16.379-6.249-22.628 0L216 308.118l-70.059-70.059c-6.248-6.248-16.379-6.248-22.628 0l-22.627 22.627c-6.248 6.248-6.248 16.379 0 22.627l104 104c6.249 6.249 16.379 6.249 22.628.001z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\"><b>How did the parents rate each element of the study?<\/b> For 92.3% of the parents, completing the symptom diary did not take too long or all that long. 67.2% felt that carrying out the nasal swabs was either of little difficulty or not difficult at all. The most common problem reported with nasal swabs was that children were crying or struggling. 86% rated taking the stool sample to be only somewhat unpleasant or not unpleasant at all. The written instructions for the extraction were found to be understandable by everyone (agree\/strongly agree).<\/span>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e8d2739 elementor-widget elementor-widget-spacer\" data-id=\"e8d2739\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2d739b0 elementor-view-default elementor-widget elementor-widget-icon\" data-id=\"2d739b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-lightbulb\" viewBox=\"0 0 352 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M96.06 454.35c.01 6.29 1.87 12.45 5.36 17.69l17.09 25.69a31.99 31.99 0 0 0 26.64 14.28h61.71a31.99 31.99 0 0 0 26.64-14.28l17.09-25.69a31.989 31.989 0 0 0 5.36-17.69l.04-38.35H96.01l.05 38.35zM0 176c0 44.37 16.45 84.85 43.56 115.78 16.52 18.85 42.36 58.23 52.21 91.45.04.26.07.52.11.78h160.24c.04-.26.07-.51.11-.78 9.85-33.22 35.69-72.6 52.21-91.45C335.55 260.85 352 220.37 352 176 352 78.61 272.91-.3 175.45 0 73.44.31 0 82.97 0 176zm176-80c-44.11 0-80 35.89-80 80 0 8.84-7.16 16-16 16s-16-7.16-16-16c0-61.76 50.24-112 112-112 8.84 0 16 7.16 16 16s-7.16 16-16 16z\"><\/path><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-265c64e elementor-widget elementor-widget-heading\" data-id=\"265c64e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-medium\">WHAT DID WE LEARN FOR THE LONG-TERM STUDY?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ace8e0f elementor-widget elementor-widget-text-editor\" data-id=\"ace8e0f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>For the majority of participating parents, keeping the symptom diary and taking the samples was acceptable and feasible. The nasal swab samples taken by the parents were suitable in quality for detecting viruses causing common cold.<\/p><p>Thanks to the parents&#8216; comments, we have made some changes, especially to the symptom diary, for the long-term study.<\/p><p>On average, the participating children had a runny nose and cough on almost a third of the study days. In the long-term study, parents are asked to take nasal swab samples whenever they have a cold. For the long-term study, we had therefore anticipated the requirement of a large number of nasal swabs for the time that the participating children are in daycare.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4b37638 elementor-widget elementor-widget-spacer\" data-id=\"4b37638\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b547e97 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"b547e97\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-94da11e elementor-widget elementor-widget-spacer\" data-id=\"94da11e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2e45152 elementor-widget elementor-widget-text-editor\" data-id=\"2e45152\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Original Publication<\/strong>: Beate Zoch, Andr\u00e9 Karch, Johannes Dreesman, Masyar Monazahian, Armin Baillot, Rafael T. Mikolajczyk. <a href=\"https:\/\/bmcinfectdis.biomedcentral.com\/articles\/10.1186\/s12879-015-1189-0\">Feasibility of a birth cohort study dedicated to assessing acute infections using symptom diaries and parental collection of biomaterials<\/a>. BMC Infectious Diseases (2015) 15:436.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0a7e96f elementor-widget elementor-widget-spacer\" data-id=\"0a7e96f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>PRELIMINARY STUDY ON FEASIBILITY As part of the preliminary study, we wanted to test the materials we had developed for recording colds and gastrointestinal diseases in small children. We also collected initial data regarding the frequency of infections in small children in day-care centers. The preliminary study was conducted from November 2013 to June 2014. [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2203","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/webszh.uk-halle.de\/loewenkids\/wp-json\/wp\/v2\/pages\/2203","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/webszh.uk-halle.de\/loewenkids\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/webszh.uk-halle.de\/loewenkids\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/webszh.uk-halle.de\/loewenkids\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/webszh.uk-halle.de\/loewenkids\/wp-json\/wp\/v2\/comments?post=2203"}],"version-history":[{"count":10,"href":"https:\/\/webszh.uk-halle.de\/loewenkids\/wp-json\/wp\/v2\/pages\/2203\/revisions"}],"predecessor-version":[{"id":2503,"href":"https:\/\/webszh.uk-halle.de\/loewenkids\/wp-json\/wp\/v2\/pages\/2203\/revisions\/2503"}],"wp:attachment":[{"href":"https:\/\/webszh.uk-halle.de\/loewenkids\/wp-json\/wp\/v2\/media?parent=2203"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}